NRIP1 (nuclear receptor interacting protein 1)

Androgen-receptor-interacting nuclear proteins.

Androgen receptor (AR) belongs to the superfamily of nuclear hormone receptors that employ complex molecular mechanisms to guide the development and physiological functions of their target tissues. Our recent work has led to the identification of four novel proteins that recognize AR zinc-finger region (ZFR) both in vivo and in vitro. One is a small nuclear RING-finger protein that possesses se...

Receptor-Interacting Protein Homotypic

Expression of nuclear receptor interacting proteins TIF-1, SUG-1, receptor interacting protein 140, and corepressor SMRT in tamoxifen-resistant breast cancer.

Regulation of gene transcription as a consequence of steroid receptor-DNA interaction is mediated via nuclear receptor interacting proteins (RIPs), including coactivator or corepressor proteins, which interact with both the receptor and components of the basic transcriptional unit and vary between cell types. The aim of this study was to test the hypothesis that resistance of some breast carcin...

بررسی میزان بیان آنزیم (receptor interacting protein 1 kinase (rip1k) در نمونه های جراحی بافت نرمال، خوش خیم و بدخیم پستان در خانم ها

مرگ سلولی برای هموستاز موجود زنده و بقای آن ضروری است. یکی از ویژگی های اصلی سلول¬های سرطانی، مقاومت در برابر مرگ است سلولهای سرطانی استراتژی های مختلفی را برای محدود کردن یا مقاومت در برابر آپوپتوز به کار می گیرند. مسیرهای مرگ سلولی توسط مجموعه¬ای از پروتئین¬ها و آنزیم¬ها کنترل می گردند. در حالت طبیعی سلول¬های آسیب دیده برای حفظ هموستاز بدن از بین می روند، اما سلول¬های سرطانی اغلب از طریق غیر ...

SMILE, a new orphan nuclear receptor SHP-interacting protein, regulates SHP-repressed estrogen receptor transactivation.

SHP (small heterodimer partner) is a well-known NR (nuclear receptor) co-regulator. In the present study, we have identified a new SHP-interacting protein, termed SMILE (SHP-interacting leucine zipper protein), which was previously designated as ZF (Zhangfei) via a yeast two-hybrid system. We have determined that the SMILE gene generates two isoforms [SMILE-L (long isoform of SMILE) and SMILE-S...